Pennsylvania Neighborhoods S
- Salem Square (3)
- Scott Township (7)
- Sewickley Hills (1)
- Shade Gap (1)
- Shadyside (61)
- Sheraden (4)
- Shiloh (5)
- Sixth Ward (1)
- Slatington Historic District (4)
- Society Hill (17)
- South Ardmore (4)
- South Duquesne Heights (2)
- South East Hills (1)
- South Easton (7)
- South Harrisburg (1)
- South Philadelphia East (23)
- South Philadelphia West (50)
- South Shore (7)
- South Side (32)
- South Suburban Erie (4)
- Southeast Community (1)
- Southeast Erie (5)
- Southeast Reading (3)
- Southside (4)
- Southside Flats (99)
- Southside Slopes (31)
- Southside-Lehigh (36)
- Southwest Center City (46)
- Southwest Reading (6)
- Southwest York (5)
- Spring Hill City View (3)
- Springetts Manor-Yorklyn (3)
- Spruce Hill (99)
- Spry (2)
- Squirrel Hill North (38)
- Squirrel Hill South (81)
- St Lawrence (1)
- St Mary's (4)
- Stadium District (8)
- Stanton Heights (12)
- Stevens (10)
- Stonybrook (1)
- Stonybrook-Wilshire (2)
- Strip District (14)
- Summer Hill (2)
- Sun Village (6)
- Swoyersville (1)