Known for its iconic hillside sign declaring "South San Francisco The Industrial City," this peninsula community has transformed from its industrial roots into a biotech powerhouse. Located just 10 miles south of San Francisco, the city offers renters convenient access to both downtown San Francisco and San Francisco International Airport. With an average rent of $2,855 for a one-bedroom apartment, South San Francisco provides more affordable housing options compared to neighboring San Francisco while maintaining excellent transportation connections via BART, Caltrain, and ferry service.

South San Francisco features distinct neighborhoods with varied rental options. The western portions of the city near Interstate 280, known as Westborough, offer hillside homes with bay views. Downtown along Grand Avenue provides a mix of smaller apartment buildings and historic charm, while the eastern side near Oyster Point Marina showcases modern apartment communities close to major employers. The city's 30 acres of parks, including Sign Hill Park and Orange Memorial Park, provide outdoor recreation with almost two miles of hiking trails and sports facilities.

Employment opportunities abound in South San Francisco, particularly in the biotech sector. The city proudly calls itself "The Birthplace of Biotechnology" with companies like Genentech (employing over 8,600 people) and other life science firms creating a strong job market. Commuters enjoy multiple transit options with the South San Francisco BART station providing express service to SFO and San Francisco, Caltrain connecting to Silicon Valley, and ferry service to Oakland and Alameda. The city's location between Highway 101 and Interstate 280 also makes for convenient driving throughout the peninsula.